The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11130780 B1

Date of Patent:

Sep. 28, 2021

Filed:

Mar. 02, 2016

Inhibitors of growth factor activation enzymes

Applicants:

James W. Janetka, St. Louis, MO (US);

Zhenfu Han, St. Louis, MO (US);

Peter Harris, St. Louis, MO (US);

Partha Karmakar, St. Louis, MO (US);

Inventors:

James W. Janetka, University City, MO (US);

Zhenfu Han, St. Louis, MO (US);

Peter Harris, Chesterfield, MO (US);

Partha Karmakar, St. Louis, MO (US);

Assignee:

Washington University, St. Louis, MO (US);

Attorney:

Stinson LLP

Primary Examiner:

D L Jones

Int. Cl.

CPC ...

A61K 51/04 (2006.01); A61K 51/08 (2006.01); C07K 5/12 (2006.01); A61K 38/00 (2006.01); C07K 5/09 (2006.01); C07K 5/11 (2006.01); C07K 5/103 (2006.01); C07K 5/097 (2006.01); G01N 33/58 (2006.01); A61K 47/64 (2017.01); A61K 49/00 (2006.01); C07B 59/00 (2006.01); C07D 277/64 (2006.01); C07K 5/072 (2006.01); C07K 5/078 (2006.01); C07K 5/107 (2006.01);

U.S. Cl.

CPC ...

C07K 5/0815 (2013.01); A61K 47/64 (2017.08); A61K 49/0052 (2013.01); A61K 49/0056 (2013.01); A61K 51/0453 (2013.01); A61K 51/08 (2013.01); C07B 59/002 (2013.01); C07B 59/008 (2013.01); C07D 277/64 (2013.01); C07K 5/06095 (2013.01); C07K 5/06156 (2013.01); C07K 5/0817 (2013.01); C07K 5/0821 (2013.01); C07K 5/101 (2013.01); C07K 5/1005 (2013.01); C07K 5/1013 (2013.01); C07K 5/1016 (2013.01); C07K 5/1019 (2013.01); C07K 5/126 (2013.01); G01N 33/582 (2013.01); A61K 38/00 (2013.01); C07B 2200/05 (2013.01); G01N 2800/7028 (2013.01);

Abstract

The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.

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