The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 28, 2021

Filed:

Jan. 30, 2020
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Ahmed Zobi, Irvine, CA (US);

Justin Stovner, Long Beach, CA (US);

Hugo Salas, Bell, CA (US);

David Duarte, Norwalk, CA (US);

Jered Haun, Irvine, CA (US);

Alan Widgerow, Irvine, CA (US);

Derek Banyard, Orange, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01L 1/00 (2006.01); B04B 9/10 (2006.01); B04B 5/04 (2006.01); G01N 35/04 (2006.01); B01L 9/00 (2006.01); G01N 35/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01L 3/50273 (2013.01); B01L 9/527 (2013.01); B04B 5/0407 (2013.01); B04B 9/10 (2013.01); G01N 35/04 (2013.01); B01L 3/502707 (2013.01); B01L 3/502753 (2013.01); B01L 2200/0621 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0883 (2013.01); B01L 2300/161 (2013.01); B01L 2400/0409 (2013.01); G01N 2035/00158 (2013.01); G01N 2035/00495 (2013.01); G01N 2035/0449 (2013.01);
Abstract

Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).


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