The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 28, 2021

Filed:

Oct. 30, 2017
Applicants:

The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);

Schepens Eye Research Institute, Boston, MA (US);

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Markus H. Frank, Cambridge, MA (US);

Natasha Y. Frank, Cambridge, MA (US);

Bruce Ksander, Boston, MA (US);

Paraskevi Evi Kolovou, Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/079 (2010.01); C12N 5/0797 (2010.01); A61K 35/30 (2015.01); A61K 9/00 (2006.01); A61L 27/38 (2006.01); C12N 5/0775 (2010.01);
U.S. Cl.
CPC ...
A61K 35/30 (2013.01); A61K 9/0051 (2013.01); A61L 27/3834 (2013.01); A61L 27/3839 (2013.01); C12N 5/0621 (2013.01); C12N 5/0623 (2013.01); C12N 5/0668 (2013.01); A61L 2430/16 (2013.01);
Abstract

Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface.


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