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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11129832 B1

PDFFull Text
Date of Patent:
Sep. 28, 2021

Filed:

Oct. 28, 2019

Biheteroaryl compounds and uses thereof

Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Anthony Estrada, San Carlos, CA (US);

Liting Dong, Shanghai, CN;

Kevin X. Chen, Shanghai, CN;

Paul Gibbons, San Francisco, CA (US);

Malcolm Huestis, South San Francisco, CA (US);

Terry Kellar, South San Francisco, CA (US);

Wen Liu, South San Francisco, CA (US);

Changyou Ma, Shanghai, CN;

Joseph P. Lyssikatos, Piedmont, CA (US);

Alan G. Olivero, Half Moon Bay, CA (US);

Snahel Patel, Foster City, CA (US);

Daniel Shore, San Francisco, CA (US);

Michael Siu, Burlingame, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:

Bradley E. Davis

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 471/08 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); A61K 31/5386 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 35/30 (2015.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 471/18 (2006.01); C07D 487/08 (2006.01); C07D 491/08 (2006.01); C07D 495/08 (2006.01); C07D 519/00 (2006.01); A61K 31/553 (2006.01); C07D 417/14 (2006.01); C07D 487/14 (2006.01); C07D 487/18 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 35/30 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); C07D 471/18 (2013.01); C07D 487/08 (2013.01); C07D 487/14 (2013.01); C07D 487/18 (2013.01); C07D 491/08 (2013.01); C07D 495/08 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R, R, R, X, X, A and Cy variable in Formula I-I all have the meaning as defined herein.

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