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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11129774 B1

PDFFull Text
Date of Patent:
Sep. 28, 2021

Filed:

May. 16, 2017

Highly loaded metal oxide materials by self-assembly for extended biologically active molecule release in medical and dental applications

Applicant:

The Governing Council of the University of Toronto, Toronto, CA;

Inventors:

Cameron Alexander Stewart, Springwater, CA;

Benjamin David Hatton, Toronto, CA;

Yoav Finer, Toronto, CA;

Assignee:

THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, Toronto, CA;

Attorney:

Hill & Schumacher

Primary Examiner:

Ernst V Arnold

Int. Cl.
CPC ...
A61K 8/14 (2006.01); A61K 6/84 (2020.01); A61L 27/56 (2006.01); C07C 279/26 (2006.01); C07D 213/74 (2006.01); C07C 279/14 (2006.01); A61K 31/4425 (2006.01); A61K 31/155 (2006.01); C07D 213/20 (2006.01); A61K 31/444 (2006.01); A61L 27/54 (2006.01); A61K 9/00 (2006.01); A61L 27/42 (2006.01); A61L 27/30 (2006.01); A61L 27/44 (2006.01); A61K 9/14 (2006.01); A61P 1/02 (2006.01); A01N 25/08 (2006.01); A61P 31/04 (2006.01); A61P 31/02 (2006.01); A61K 9/51 (2006.01); A61L 27/32 (2006.01); A61K 31/785 (2006.01); A61L 27/12 (2006.01); A61L 27/10 (2006.01); A61L 27/02 (2006.01); A01N 43/40 (2006.01); A01N 47/44 (2006.01); A61K 31/20 (2006.01); A61K 6/20 (2020.01); A61K 6/35 (2020.01); A61K 6/40 (2020.01); A61K 6/54 (2020.01); A61K 6/71 (2020.01); A61K 6/74 (2020.01); A61K 6/76 (2020.01); A61K 6/80 (2020.01); A61K 6/86 (2020.01); A61K 6/802 (2020.01); A61K 6/849 (2020.01); A61K 6/853 (2020.01); A61K 6/864 (2020.01); A61K 6/871 (2020.01); C08K 3/22 (2006.01); C08K 3/32 (2006.01); C08L 33/12 (2006.01);
U.S. Cl.
CPC ...
A61K 6/84 (2020.01); A01N 25/08 (2013.01); A01N 43/40 (2013.01); A01N 47/44 (2013.01); A61K 6/20 (2020.01); A61K 6/35 (2020.01); A61K 6/40 (2020.01); A61K 6/54 (2020.01); A61K 6/71 (2020.01); A61K 6/74 (2020.01); A61K 6/76 (2020.01); A61K 6/80 (2020.01); A61K 6/802 (2020.01); A61K 6/849 (2020.01); A61K 6/853 (2020.01); A61K 6/86 (2020.01); A61K 6/864 (2020.01); A61K 6/871 (2020.01); A61K 9/0024 (2013.01); A61K 9/0063 (2013.01); A61K 9/143 (2013.01); A61K 9/5115 (2013.01); A61K 31/155 (2013.01); A61K 31/20 (2013.01); A61K 31/444 (2013.01); A61K 31/4425 (2013.01); A61K 31/785 (2013.01); A61L 27/025 (2013.01); A61L 27/10 (2013.01); A61L 27/105 (2013.01); A61L 27/12 (2013.01); A61L 27/306 (2013.01); A61L 27/32 (2013.01); A61L 27/425 (2013.01); A61L 27/427 (2013.01); A61L 27/446 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61P 1/02 (2018.01); A61P 31/02 (2018.01); A61P 31/04 (2018.01); C07C 279/14 (2013.01); C07C 279/26 (2013.01); C07D 213/20 (2013.01); C07D 213/74 (2013.01); C08K 3/22 (2013.01); C08K 3/32 (2013.01); C08L 33/12 (2013.01); A61L 2300/206 (2013.01); A61L 2300/208 (2013.01); A61L 2300/404 (2013.01); C08K 2003/2227 (2013.01); C08K 2003/2237 (2013.01); C08K 2003/2296 (2013.01); C08K 2003/325 (2013.01); C08L 2203/02 (2013.01);
Abstract

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

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