The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2021
Filed:
Jan. 25, 2018
Applicant:
Intelligent Virus Imaging Inc., Southern Pines, NC (US);
Inventors:
Mathieu Colomb-Delsuc, Älvsjo, SE;
Lars Haag, Nykvarn, SE;
Rickard Nordström, Tullinge, SE;
Martin Ryner, Huddinge, SE;
Assignee:
INTELLIGENT VIRUS IMAGING INC., Southern Pines, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); G01N 1/38 (2006.01); G01N 15/10 (2006.01); C12Q 1/70 (2006.01);
U.S. Cl.
CPC ...
G01N 15/10 (2013.01); C12N 7/00 (2013.01); C12Q 1/70 (2013.01); G01N 1/38 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14123 (2013.01);
Abstract
The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.