The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 21, 2021

Filed:

May. 09, 2018
Applicant:

Cyano Biotech Gmbh, Berlin, DE;

Inventors:

Heike Enke, Berlin, DE;

Wolfram Lorenzen, Berlin, DE;

Stefan Jahns, Berlin, DE;

Dan Enke, Berlin, DE;

Timo Niedermeyer, Halle Saale, DE;

Julia Moschny, Sulzbach-Rosenberg, DE;

Assignee:

Cyano Biotech GmbH, Berlin, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/64 (2017.01); C07K 7/56 (2006.01); C12N 1/20 (2006.01); C12P 21/04 (2006.01); C12P 21/02 (2006.01); A61K 47/68 (2017.01); C07K 7/58 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); A61K 47/64 (2017.08); A61K 47/6829 (2017.08); C07K 7/56 (2013.01); C07K 7/58 (2013.01); C12N 1/20 (2013.01); C12N 2500/32 (2013.01); C12N 2500/33 (2013.01);
Abstract

A method is used for producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), including the steps of: a) growing a modified non-ribosomal peptide producing cyanobacteria strain in a culture media, h) adding one or more modified substrates, preferably modified amino acids to said culture, and c) inoculating the non-ribosomal peptide, producing strain the presence of said modified substrates. The thus modified non-ribosomal peptide may be used for the therapy of various diseases.


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