The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 21, 2021

Filed:

Oct. 29, 2018
Applicant:

Georgia Tech Research Corporation, Atlanta, GA (US);

Inventors:

Kan Wang, Atlanta, GA (US);

Ben Wang, Atlanta, GA (US);

Chun Zhang, Atlanta, GA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); C12M 1/00 (2006.01); C12N 5/00 (2006.01); C12M 1/12 (2006.01); B01L 3/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0062 (2013.01); B01L 3/567 (2013.01); C12M 23/26 (2013.01); C12M 25/14 (2013.01); C12N 5/0068 (2013.01); B01L 2400/06 (2013.01); C12M 3/00 (2013.01); C12M 23/20 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2513/00 (2013.01); C12N 2521/00 (2013.01); C12N 2533/54 (2013.01);
Abstract

Systems and methods for culturing cells are disclosed. A system can comprise an auxetic scaffold substrate. The substrate can comprise scaffold units at least a portion of which comprise living cells. Scaffold units can be configured to transition between a contracted state and an expanded state. Units can comprise an interior void having a contracted volume in the contracted state and an expanded volume in the expanded state, in which the expanded volume is greater than the contracted volume. Units can be configured to pass a fluid into the interior void of the corresponding unit when the unit transitions from the contracted state to the expanded state. Units can be configured to pass the fluid out of the interior void of the corresponding unit when the unit transitions from the expanded state to the contracted state.


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