The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2021
Filed:
Jan. 15, 2021
Denali Therapeutics Inc., South San Francisco, CA (US);
Mark S. Dennis, South San Francisco, CA (US);
Zhenyu Gu, South San Francisco, CA (US);
Mihalis S. Kariolis, South San Francisco, CA (US);
Cathal S. Mahon, South San Francisco, CA (US);
Kathryn M. Monroe, South San Francisco, CA (US);
Joshua I. Park, South San Francisco, CA (US);
Rachel Prorok, South San Francisco, CA (US);
Adam P. Silverman, South San Francisco, CA (US);
Bettina Van Lengerich, South San Francisco, CA (US);
Denali Therapeutics Inc., South San Francisco, CA (US);
Abstract
In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.