The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2021
Filed:
Jun. 04, 2019
Applicant:
Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
Inventors:
Victor J. Hruby, Tucson, AZ (US);
Minying Cai, Tucson, AZ (US);
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); A61K 38/10 (2006.01); A61K 9/00 (2006.01); A61K 47/24 (2006.01); A61K 9/107 (2006.01); A61K 9/70 (2006.01); C07K 14/68 (2006.01); C07K 14/685 (2006.01); C07K 14/72 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); A61K 9/0014 (2013.01); A61K 9/107 (2013.01); A61K 9/7084 (2013.01); A61K 38/10 (2013.01); A61K 47/24 (2013.01); C07K 7/08 (2013.01); C07K 14/68 (2013.01); C07K 14/685 (2013.01); C07K 14/723 (2013.01);
Abstract
Modulators of melanocortin receptors (MCR) are provided herein. An MC5R peptide ligand is represented by to Formula 1:R-Nle-[Xaa-Yaa-(NMe)D-Nal(2')-Arg-Trp-(NMe)Zaa]-R.Rcan be an acetyl, a glycosylated amino acid, —CO—(CH)CH, or —CO—(CH)CFwith n ranging from 1 to 6. Rcan be an —CONH, —COOH, or —CHOH. Xaa, Yaa, and Zaa can each be a natural amino acid or an unnatural amino acid.