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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11124514 B1

PDFFull Text
Date of Patent:
Sep. 21, 2021

Filed:

Sep. 27, 2019

Compositions and methods

Applicant:

Intra-cellular Therapies, Inc., New York, NY (US);

Inventors:

Sharon Mates, New York, NY (US);

Robert Davis, San Diego, CA (US);

Kimberly Vanover, New York, NY (US);

Lawrence Wennogle, Hillsborough, NJ (US);

Assignee:

INTRA-CELLULAR THERAPIES, INC., New York, NY (US);

Attorney:

Hoxie & Associates LLC

Primary Examiner:

Shengjun Wang

Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/13 (2006.01); A61K 31/445 (2006.01); A61K 31/44 (2006.01); A61K 31/27 (2006.01); C07D 471/14 (2006.01); A61K 45/06 (2006.01); A61K 31/5383 (2006.01); A61K 31/4985 (2006.01); A61P 25/28 (2006.01); C07D 471/16 (2006.01);
U.S. Cl.
CPC ...
C07D 471/14 (2013.01); A61K 31/445 (2013.01); A61K 31/4985 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01); C07D 471/16 (2013.01);
Abstract

The present invention relates to use of particular substituted heterocycle fused gamma-carbolines as described herein, in free, pharmaceutically acceptable salt or prodrug form, and pharmaceutical composition comprising the same optionally in combination with one or more agents, for the prophylaxis or treatment of one or more disorders associated with dementia, particularly behavioral or mood disturbances (e.g., agitation/aggression), psychosis, depression and sleep disturbances among others in patients suffering from dementia.

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