The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2021
Filed:
Aug. 06, 2018
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Assignee:
California Institute of Technology, Pasadena, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 409/06 (2006.01); C07D 207/27 (2006.01); C07D 207/273 (2006.01); C07D 207/277 (2006.01);
U.S. Cl.
CPC ...
C07D 409/06 (2013.01); C07D 207/27 (2013.01); C07D 207/273 (2013.01); C07D 207/277 (2013.01);
Abstract
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam of formula (IIa): with a chiral Ni catalyst, an aryl nitrile, and an aryl halide to provide compounds of formula (Ia):