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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11123400 B1

PDFFull Text
Date of Patent:
Sep. 21, 2021

Filed:

Sep. 19, 2016

Broken or folded helical peptide or peptide analog exhibiting antimicrobial activity against gram-negative bacteria, and use thereof

Applicant:

Seoul National University R&db Foundation, Seoul, KR;

Inventors:

Jaehoon Yu, Gyeonggi-do, KR;

Yan Lee, Seoul, KR;

Soonsil Hyun, Seoul, KR;

Seo Yeon Kim, Seoul, KR;

Sun Mi Jin, Seoul, KR;

Yunhwa Choi, Seoul, KR;

Doyeon Jo, Seoul, KR;

Seonju Lee, Seoul, KR;

Assignee:

SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul, KR;

Attorneys:

Hultquist, PLLC

Steven J. Hultquist

Primary Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
A61K 38/10 (2006.01); A01N 37/18 (2006.01); A61K 38/04 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 38/16 (2006.01); C07K 7/08 (2006.01); A61K 31/616 (2006.01); A61K 31/431 (2006.01); A61K 31/192 (2006.01); A61K 31/05 (2006.01); A61K 31/12 (2006.01); A61K 31/5377 (2006.01); A61K 31/366 (2006.01); A61P 31/04 (2006.01); A61P 29/00 (2006.01); A61P 9/00 (2006.01); A61K 38/06 (2006.01); A61K 38/00 (2006.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
A61K 38/16 (2013.01); A61K 31/05 (2013.01); A61K 31/12 (2013.01); A61K 31/192 (2013.01); A61K 31/366 (2013.01); A61K 31/431 (2013.01); A61K 31/5377 (2013.01); A61K 31/616 (2013.01); A61K 38/04 (2013.01); A61K 38/06 (2013.01); A61K 38/10 (2013.01); A61P 9/00 (2018.01); A61P 29/00 (2018.01); A61P 31/04 (2018.01); C07K 7/08 (2013.01); A61K 38/00 (2013.01); A61K 47/6455 (2017.08);
Abstract

The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.

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