The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 14, 2021

Filed:

Aug. 12, 2016
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Jonathan Barasch, New York, NY (US);

Katherine Xu, New York, NY (US);

Paul Rosenstiel, New York, NY (US);

Paolo Guarnieri, New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/573 (2006.01); G01N 33/68 (2006.01); G01N 33/70 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); G01N 33/68 (2013.01); G01N 33/6893 (2013.01); G01N 33/70 (2013.01); G01N 2333/96486 (2013.01); G01N 2800/347 (2013.01);
Abstract

The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TACSTD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.


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