The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Apr. 21, 2020
Applicant:
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Inventors:
Benjamin J. Pavlik, Lincoln, NE (US);
Paul Blum, Lincoln, NE (US);
Kevin Van Cott, Hickman, NE (US);
Assignee:
The Board of Regents of the University of Nebraska, Lincoln, NE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01); C07K 14/33 (2006.01); C12N 15/62 (2006.01); A61K 47/64 (2017.01); A61K 38/45 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); A61K 38/45 (2013.01); A61K 47/6415 (2017.08); A61K 49/0056 (2013.01); C07K 14/33 (2013.01); C12N 15/62 (2013.01); C12Y 204/02 (2013.01); C12Y 304/24069 (2013.01); C07K 2319/33 (2013.01); Y02A 50/30 (2018.01);
Abstract
An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype oftoxin, while the payload region is derived from a different sub-serotype oftoxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.