The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 14, 2021

Filed:

Sep. 21, 2016
Applicant:

Dongguk University Industry-academy Cooperation Foundation, Seoul, KR;

Inventors:

Jongpil Kim, Seoul, KR;

Junsang Yoo, Seoul, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0793 (2010.01); A61K 35/30 (2015.01); C07K 14/47 (2006.01); C12N 13/00 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0619 (2013.01); A61K 35/30 (2013.01); A61P 25/00 (2018.01); C07K 14/4702 (2013.01); C12N 13/00 (2013.01); C12N 2501/60 (2013.01); C12N 2506/1307 (2013.01); C12N 2510/00 (2013.01); C12N 2529/00 (2013.01);
Abstract

The present invention relates to a method for direct transdifferentiation into neurons using metal nanoparticles magnetized by an electromagnetic field, and to a cell therapeutic agent for the treatment of cerebral nerve diseases, comprising neurons differentiated by the method. In the present invention, it was specifically verified that the direct transdifferentiation efficiency into neurons can be remarkably improved through the above method and the symptoms of cerebral nerve diseases, such as a stroke, can be effectively alleviated. Therefore, in the treatment of degenerative cerebral nerve diseases, the target therapy is expected to be implemented through a more fundamental approach.


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