The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Apr. 19, 2018
Teva Pharmaceuticals Australia Pty Ltd, Macquarie Park, AU;
Adam Clarke, Macquarie Park, AU;
Matthew Pollard, Macquarie Park, AU;
Anthony Gerard Doyle, Macquarie Park, AU;
Collette Behrens, Macquarie Park, AU;
Tetsuo Yamagishi, Macquarie Park, AU;
David S. Wilson, Jr., Redwood City, CA (US);
Sarah L. Pogue, Fremont, CA (US);
Tetsuya Taura, Palo Alto, CA (US);
Teva Pharmaceuticals Australia Pty Ltd, Macquarie Park, AU;
Abstract
Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.