The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 14, 2021

Filed:

Feb. 24, 2020
Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Oliver Ast, Bassersdorf, CH;

Marina Bacac, Zurich, CH;

Sabine Imhof-Jung, Planegg, DE;

Christiane Neumann, Niederweningen, CH;

Christian Klein, Bonstetten, CH;

Stefan Klostermann, Neuried, DE;

Michael Molhoj, Munich, DE;

Joerg Thomas Regula, Munich, DE;

Wolfgang Schaefer, Mannheim, DE;

Pablo Umana, Wollerau, CH;

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); C07K 16/2878 (2013.01); C07K 16/2887 (2013.01); C07K 16/3053 (2013.01); C07K 16/32 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/526 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/64 (2013.01); C07K 2317/66 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract

The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.


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