The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Feb. 05, 2019
Sirna Therapeutics, Inc., Cambridge, MA (US);
David Tellers, West Point, PA (US);
Steven L. Colletti, West Point, PA (US);
Vadim Dudkin, West Point, PA (US);
Jeffrey Aaronson, West Point, PA (US);
Aaron Momose, West Point, PA (US);
Thomas Joseph Tucker, West Point, PA (US);
Yu Yuan, Orlando, FL (US);
Kathleen B. Calati, Rahway, NJ (US);
Lu Tian, Jamison, PA (US);
Rubina G. Parmar, West Point, PA (US);
Anthony W. Shaw, West Point, PA (US);
Weimin Wang, West Point, PA (US);
Rachel Anne Storr, West Point, PA (US);
Marina Busuek, West Point, PA (US);
Robert A. Kowtoniuk, West Point, PA (US);
Sirna Therapeutics, Inc., Cambridge, MA (US);
Abstract
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.