The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 14, 2021

Filed:

Apr. 04, 2018
Applicant:

University of Mississippi, University, MS (US);

Inventors:

Mahmoud A. ElSohly, Oxford, MS (US);

Waseem Gul, Oxford, MS (US);

Mohamed M. Radwan, Oxford, MS (US);

Amira Samir Wanas, Oxford, MS (US);

Assignee:

UNIVERSITY OF MISSISSIPPI, University, MS (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 37/74 (2006.01); C07C 37/82 (2006.01); A01H 6/28 (2018.01); A61K 31/05 (2006.01); C07C 37/00 (2006.01); C07C 37/86 (2006.01); C07C 39/23 (2006.01); G01N 30/02 (2006.01); G01N 30/88 (2006.01);
U.S. Cl.
CPC ...
C07C 37/74 (2013.01); A01H 6/28 (2018.05); A61K 31/05 (2013.01); C07C 37/004 (2013.01); C07C 37/82 (2013.01); C07C 37/86 (2013.01); C07C 39/23 (2013.01); G01N 30/02 (2013.01); G01N 2030/884 (2013.01);
Abstract

Δ-Tetrahydrocannabinol (Δ-THC or THC) and cannabidiol (CBD) are major constituents of theplant that have pharmacological properties with potential therapeutic value. This invention is directed to processes for large scale isolation of these two and other cannabinoids from theplant. This is accomplished through the discovery that protected amino acid esters of the cannabinoids are easier to separate using normal phase silica column chromatography. Mild base hydrolysis of the esters regenerates the free cannabinoids in a purified form. The invention is also applicable to the isolation of other cannabinoids fromextracts.


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