The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Jan. 29, 2021
Applicant:
Texas Children's Hospital, Houston, TX (US);
Inventors:
Eric A. Tanifum, Richmond, TX (US);
Ketankumar B. Ghaghada, Sugar Land, TX (US);
Ananth V. Annapragada, Manvel, TX (US);
Assignee:
Texas Children's Hospital, Houston, TX (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/18 (2006.01); A61K 47/24 (2006.01); A61K 49/10 (2006.01);
U.S. Cl.
CPC ...
A61K 49/1812 (2013.01); A61K 47/24 (2013.01); A61K 49/108 (2013.01);
Abstract
A liposomal composition ('ADx-001') is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.