The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Nov. 13, 2019
Memorial Sloan Kettering Cancer Center, New York, NY (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
Jaeki Min, Memphis, TN (US);
Daniel C. Scott, Marion, AR (US);
Deepak Bhasin, Cordova, TN (US);
Brenda A. Schulman, Memphis, TN (US);
Bhuvanesh Singh, Old Westbury, NY (US);
Jared T. Hammill, Memphis, TN (US);
R. Kiplin Guy, Memphis, TN (US);
MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US);
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, Memphis, TN (US);
Abstract
In one aspect, the invention relates to substituted 1-phenyl-3-(piperidin-4-yl)urea analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the DCN1-UBC12 interaction inhibitors of DCN1-mediated cullin-RING ligase activity, methods of making same, pharmaceutical compositions comprising same, methods of treating disorders using the disclosed compounds and compositions, methods of treating disorders associated with a DCN1-UBC12 interaction dysfunction, methods of treating disorders associated with a DCN1-mediated cullin-RING ligase activity dysfunction, methods of male contraception comprising the disclosed compounds and compositions, and kits comprising the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.