The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Jan. 03, 2020
Emory University, Atlanta, GA (US);
Bar-ilan University, Ramat Gan, IL;
Children's Healthcare of Atlanta, Inc., Atlanta, GA (US);
Nael McCarty, Atlanta, GA (US);
Guiying Cui, Atlanta, GA (US);
Hanoch Senderowitz, Tel Aviv, IL;
Netaly Khazanov, Petah-Tiqva, IL;
Emory University, Atlanta, GA (US);
Bar-Ilan University, Ramat Gan, IL;
Children's Healthcare of Atlanta, Inc., Atlanta, GA (US);
Abstract
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N'-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N′-benzylidene-acetohydrazide compound is ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.