The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Jun. 27, 2017
Applicant:
Kyoto University, Kyoto, JP;
Inventors:
Hirohide Saito, Kyoto, JP;
Yoshihiko Fujita, Kyoto, JP;
Assignee:
Kyoto University, Kyoto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2018.01); C12N 5/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 15/09 (2013.01); C12N 5/10 (2013.01); C12N 2840/102 (2013.01); C12Q 1/68 (2013.01);
Abstract
An mRNA forcibly expresses a protein gene in response to a miRNA, and a method for forcibly expressing the same, are provided. An artificial mRNA comprising a sequence encoding a protein gene, a miRNA target sequence linked to the 3'-terminal side of a Poly A sequence, and a translational repression sequence linked to the 3′-terminal side of the miRNA target sequence; and a method for expressing a protein gene in response to the expression of a miRNA, comprising a step of introducing the artificial mRNA into a cell.