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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11111496 B1

PDFFull Text
Date of Patent:
Sep. 07, 2021

Filed:

Jan. 30, 2018

Methods and microorganisms for making 2,3-butanediol and derivatives thereof from c1 carbons

Applicant:

Intrexon Corporation, Blacksburg, VA (US);

Inventors:

Xinhua Zhao, Dublin, CA (US);

Mark Anton Held, Emeryville, CA (US);

Tina Huynh, Oakland, CA (US);

Lily Yuin Chao, San Francisco, CA (US);

Na Trinh, Walnut Creek, CA (US);

Matthias Helmut Schmalisch, South San Francisco, CA (US);

Bryan Yeh, Walnut Creek, CA (US);

James Kealey, Sebastopol, CA (US);

Kevin Lee Dietzel, Pacifica, CA (US);

Assignee:

PRECIGEN, INC., Germantown, MD (US);

Attorneys:

Gene J. Yao

Barnes & Thornburg LLP

Primary Examiner:

Suzanne M Noakes

Int. Cl.
CPC ...
C12N 15/52 (2006.01); C12N 1/20 (2006.01); C12N 9/00 (2006.01); C12N 9/88 (2006.01); C12N 15/74 (2006.01); C12P 5/02 (2006.01); C12P 7/16 (2006.01); C12P 7/18 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/52 (2013.01); C12N 1/20 (2013.01); C12N 9/0006 (2013.01); C12N 9/1022 (2013.01); C12N 9/88 (2013.01); C12N 15/74 (2013.01); C12P 5/023 (2013.01); C12P 7/16 (2013.01); C12P 7/18 (2013.01); C12Y 101/01304 (2013.01); C12Y 202/01006 (2013.01); C12Y 401/01004 (2013.01); C12Y 401/01005 (2013.01);
Abstract

Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

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