The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Oct. 04, 2016
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Gonçalo Rodrigues, Berkeley, CA (US);
David V. Schaffer, Danville, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C08L 51/00 (2006.01); C12N 5/079 (2010.01); C07D 471/04 (2006.01); C12N 5/00 (2006.01); A61K 35/28 (2015.01);
U.S. Cl.
CPC ...
C08L 51/006 (2013.01); C07D 471/04 (2013.01); C12N 5/0018 (2013.01); C12N 5/0622 (2013.01); A61K 35/28 (2013.01); C08L 2203/02 (2013.01); C12N 2501/385 (2013.01); C12N 2501/41 (2013.01); C12N 2501/415 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2539/10 (2013.01);
Abstract
The present disclosure provides a three-dimensional culture system comprising a biocompatible polymer and a combination of factors in an amount effective to induce differentiation of oligodendrocyte precursors and/or oligodendrocytes from pluripotent stem cells. The present disclosure provides methods of generating oligodendrocyte precursors and/or oligodendrocytes using a three-dimensional culture system of the present disclosure. The present disclosure provides methods to treat neurological diseases and demyelinating diseases.