The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Sep. 12, 2017
Applicant:
Wuxi Biologies Ireland Limited, Dublin, IE;
Inventors:
Jieying Liu, Shanghai, CN;
Jing Li, Lexington, MA (US);
Assignee:
WUXI BIOLOGICS IRELAND LIMITED, Dublin, IE;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/40 (2006.01); A61K 39/395 (2006.01); C12N 9/64 (2006.01); A61P 3/06 (2006.01); A61P 3/00 (2006.01); A61P 37/04 (2006.01); A61P 9/00 (2006.01); A61K 39/00 (2006.01); A61P 31/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 39/395 (2013.01); A61P 3/00 (2018.01); A61P 3/06 (2018.01); A61P 9/00 (2018.01); A61P 37/04 (2018.01); C12N 9/6454 (2013.01); A61K 2039/505 (2013.01); A61P 31/00 (2018.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present disclosure provides monoclonal antibodies against Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9), which can block the binding of PCSK9 to low-density lipoprotein (LDL) receptor, and therefore lower the level low-density lipoprotein cholesterol (LDL-C). The antibodies of disclosure provide very potent agents for the treatment of multiple Cardiovascular diseases (CVDs).