The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Nov. 21, 2018
Roche Glycart Ag, Schlieren, CH;
Oliver Ast, Bassersdorf, CH;
Peter Bruenker, Hittnau, CH;
Anne Freimoser-Grundschober, Zurich, CH;
Sylvia Herter, Regensdorf, CH;
Thomas U. Hofer, Zurich, CH;
Ralf Hosse, Cham, CH;
Christian Klein, Bonstetten, CH;
Ekkehard Moessner, Kreuzlingen, CH;
Valeria G. Nicolini, Erlenbach/ZH, CH;
Pablo Umana, Wollerau, CH;
ROCHE GLYCART AG, Schlieren, CH;
Abstract
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.