The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Jan. 15, 2020
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Eric N. Olson, University Park, TX (US);
Rhonda S. Bassel-Duby, Dallas, TX (US);
Catherine A. Makarewich, Dallas, TX (US);
Benjamin R. Nelson, Dallas, TX (US);
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 45/06 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 38/1709 (2013.01); A61K 45/06 (2013.01); A61K 48/0058 (2013.01);
Abstract
The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.