The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Apr. 10, 2020
Applicant:
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Inventors:
Donna M. Huryn, Allentown, PA (US);
Peter Wipf, Pittsburgh, PA (US);
Jennifer Rubin Grandis, Pittsburgh, PA (US);
Matthew G. LaPorte, Pittsburgh, PA (US);
Paul A. Johnston, Sewickley, PA (US);
Mark E. Schurdak, Pittsburgh, PA (US);
Raffaele Colombo, Pittsburgh, PA (US);
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61P 35/00 (2018.01);
Abstract
Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.