The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
May. 23, 2018
Ustav Organicke Chemie a Biochemie Av Cr, V.v.i., Prague, CZ;
Ustav Experimentalni Mediciny Av Cr, V.v.i., Prague, CZ;
Viktor Kolman, Prague, CZ;
Filip Kalcic, Karlovy Vary, CZ;
Zlatko Janeba, Prague, CZ;
Zdenek Zidek, Prague, CZ;
USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., Prague, CZ;
Abstract
The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.