The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Dec. 08, 2017
Applicant:
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Xiaoting Zhang, Cincinnati, OH (US);
Peixuan Guo, Cincinnati, OH (US);
Assignees:
University of Cincinnati, Cincinnati, OH (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); A61P 35/00 (2006.01); A61K 31/4196 (2006.01); A61K 31/566 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6929 (2017.08); A61K 31/4196 (2013.01); A61K 31/566 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/32 (2013.01);
Abstract
RNA nanoparticles functionalized with a HER2-targeting RNA aptamer and at least one MED1 siRNA for targeted delivery of MED1 siRNA to human cancer cells via human epidermal growth factor receptor 2 (HER2) receptors, pharmaceutical compositions of the inventive RNA nanoparticles, and methods for treating breast, HER2-implicated cancers, and in particular therapeutic-resistant cancer such as tamoxifen-resistant breast cancer, by administering pharmaceutical compositions of the inventive RNA nanoparticles.