The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Sep. 16, 2019
Applicant:
Inventprise, Llc, Redmond, WA (US);
Inventors:
Subhash V. Kapre, Redmond, WA (US);
Ivan A. Olave, Kirkland, WA (US);
Assignee:
Inventprise, LLC, Redmond, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/15 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 47/14 (2017.01); C12N 7/00 (2006.01); A61K 9/19 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/15 (2013.01); A61K 9/19 (2013.01); A61K 47/14 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C12N 7/00 (2013.01); A61K 2039/5254 (2013.01); C12N 2720/12334 (2013.01);
Abstract
The invention is directed to an oral vaccine composed of a micronized freeze-dried rotavirus particle suspension with buffering excipients in a non-aqueous liquid. This IVT-06 formulation has imparted heat stability by protecting the virus at temperatures of 30° C. and 40° C. for at least twelve months. Extrapolations from the 12-month stability data indicate a shelf life of more than two years at 30° C., and six months at 50° C. In addition, for ease of administration, the formulated dose has a volume of 0.5 mL.