The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2021
Filed:
Feb. 21, 2019
Applicant:
Korea University Research and Business Foundation, Seoul, KR;
Inventors:
Kyung-Mi Lee, Seoul, KR;
Jeongwon Sohn, Seoul, KR;
Seon Ah Lim, Seoul, KR;
Jang-Mi Lim, Pohang-Si, KR;
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4184 (2006.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); A61K 35/00 (2006.01); A61K 35/02 (2015.01); A61K 35/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C12N 5/0646 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/585 (2013.01); C12N 2501/998 (2013.01); C12N 2501/999 (2013.01);
Abstract
Provided are a method of ex-vivo culture of natural killer (NK) cells by treating the cells with a reactive oxygen species (ROS) inhibitor and/or a p53 protein inhibitor; and a composition comprising the cultured NK cells. By reducing the activity of ROS and p53 proteins during ex-vivo culture, NK cells may have achieved greater expansion efficiency without altering their anti-tumor cytotoxicity.