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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11110108 B1

PDFFull Text
Date of Patent:
Sep. 07, 2021

Filed:

Sep. 27, 2017

Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors

Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Diane M. Boucher, Boston, MA (US);

Shawn M. Hillier, Boston, MA (US);

Wanjung Tsai, Boston, MA (US);

Brian Hare, Boston, MA (US);

William Markland, Boston, MA (US);

David A. Newsome, Boston, MA (US);

Marina S. Penney, Boston, MA (US);

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED, Boston, MA (US);

Attorneys:

Dechert LLP

Andrea L. C. Reid

Danielle M. Nihan

Primary Examiner:

Snigdha Maewall

Int. Cl.
CPC ...
A61K 31/704 (2006.01); A61P 35/00 (2006.01); A61K 9/127 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/704 (2013.01); A61K 9/1271 (2013.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R, Q, Ring A, and Ring B are as defined herein.

Find Patent Forward Citations

Boucher, Diane. (2021). Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors (U.S. Patent No. 11110108). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11110108

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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