The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 07, 2021

Filed:

Sep. 19, 2019
Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Sacha Holland, San Francisco, CA (US);

Rajinder Singh, Belmont, CA (US);

Somasekhar Bhamidipati, Foster City, CA (US);

Pingyu Ding, Foster City, CA (US);

Rao Kolluri, Foster City, CA (US);

Ihab Darwish, San Carlos, CA (US);

Esteban Masuda, Menlo Park, CA (US);

Jiaxin Yu, San Carlos, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 31/4545 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4545 (2013.01); A61K 31/519 (2013.01); C07D 471/04 (2013.01); C07D 519/00 (2013.01);
Abstract

Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, Y and Z are as described herein. In certain embodiments, a compound disclosed herein inhibits a cellular TAM receptor, and can be used to treat disease mediated by or involving the TAM receptor family.


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