The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
May. 04, 2017
Waters Technologies Corporation, Milford, MA (US);
Martin Gilar, Franklin, MA (US);
Richard W. Andrews, Rehoboth, MA (US);
Peyton C. Beals, Wrentham, MA (US);
Thomas McDonald, Littleton, MA (US);
Keith Fadgen, Hope Valley, RI (US);
Jordan Kornfeld, Norfolk, MA (US);
Geoff Gerhardt, Woonsocket, RI (US);
Sylvain Cormier, Mendon, MA (US);
WATERS TECHNOLOGIES CORPORATION, Milford, MA (US);
Abstract
A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.