The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 31, 2021

Filed:

May. 22, 2015
Applicants:

The Scripps Research Institute, La Jolla, CA (US);

Northwestern University, Evanston, IL (US);

Inventors:

Daniel Salomon, San Diego, CA (US);

Josh Levitsky, Evanston, IL (US);

Sunil Kurian, San Diego, CA (US);

Michael Abecassis, Highland Park, IL (US);

Assignees:

The Scripps Research Institute, La Jolla, CA (US);

Northwestern University, Evanston, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); G01N 33/574 (2006.01); G01N 33/50 (2006.01); G16H 50/30 (2018.01); G16H 20/40 (2018.01); G16H 20/10 (2018.01); G16H 20/17 (2018.01); G16H 50/70 (2018.01); G16H 50/20 (2018.01); G16H 40/63 (2018.01); G16H 10/20 (2018.01); G16H 10/40 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); G01N 33/5088 (2013.01); G16H 20/10 (2018.01); G16H 20/17 (2018.01); G16H 20/40 (2018.01); G16H 40/63 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01); C12Q 2537/165 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/245 (2013.01); G16H 10/20 (2018.01); G16H 10/40 (2018.01); Y02A 90/10 (2018.01);
Abstract

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.


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