The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
Jan. 31, 2019
Applicant:
Japan Tobacco Inc., Tokyo, JP;
Inventors:
Assignee:
JAPAN TOBACCO INC., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07C 269/00 (2006.01); C07C 271/28 (2006.01); C07D 231/56 (2006.01); C07D 405/04 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); C07C 269/00 (2013.01); C07C 271/28 (2013.01); C07D 231/56 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); A61K 31/5377 (2013.01);
Abstract
The present invention aims to provide a new method for producing an indole compound or a salt thereof, which has an ITK inhibitory action, and is useful for the prophylaxis or treatment of inflammatory disease. The present invention is a method for producing N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl]-N-methyl-(2S)-2-(morpholin-4-yl)propanamide, which comprises a step of reacting