The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
May. 02, 2014
Applicants:
GE Healthcare Limited, Buckinghamshire, GB;
University of Southampton, Southampton, GB;
Inventors:
Assignees:
GE HEALTHCARE UK LIMITED, Hampshire, GB;
University of Southampton, Hampshire, GB;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/04 (2006.01); C07F 5/00 (2006.01); C07D 255/02 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0482 (2013.01); C07D 255/02 (2013.01); C07F 5/003 (2013.01);
Abstract
A method of labelling biological molecules withF, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.