The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
Oct. 14, 2014
Applicant:
Seagen Inc., Bothell, WA (US);
Inventors:
Assignee:
SEAGEN INC., Bothell, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/28 (2006.01); A61K 47/60 (2017.01); A61K 47/54 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6817 (2017.08); A61K 47/549 (2017.08); A61K 47/60 (2017.08); A61K 47/6819 (2017.08); A61K 47/6851 (2017.08); A61K 47/6883 (2017.08); A61K 47/6885 (2017.08); C07K 16/28 (2013.01); C07K 16/2878 (2013.01); A61K 2039/505 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.