The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
Jan. 06, 2017
Applicant:
Apg Therapeutics, Inc., Millbrae, CA (US);
Inventors:
Joaquim Trias, Millbrae, CA (US);
Jaume Pons, San Francisco, CA (US);
David Shelton, Oakland, CA (US);
Antoni Planas, Sant Cugat del Valles, ES;
Assignee:
APG Therapeutics, Inc., Millbrae, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/59 (2017.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); A61K 48/00 (2006.01); C07J 9/00 (2006.01); C08G 73/02 (2006.01); C07K 16/28 (2006.01); C07K 14/54 (2006.01);
U.S. Cl.
CPC ...
A61K 47/59 (2017.08); A61K 47/65 (2017.08); A61K 47/68 (2017.08); A61K 48/0041 (2013.01); C07J 9/00 (2013.01); C07K 16/28 (2013.01); C08G 73/0206 (2013.01); C07K 14/5406 (2013.01); C07K 2317/31 (2013.01); C07K 2317/82 (2013.01); C07K 2319/03 (2013.01); C07K 2319/033 (2013.01); C07K 2319/33 (2013.01);
Abstract
The present application provides PEI compounds comprising a linker, PEI-polypeptide conjugates (e.g., PEI-antibody conjugates), and complexes thereof comprising a biologically active molecule. Methods of preparing and using the compounds, conjugates and complexes are further provided. The PEI-polypeptide conjugates and complexes are useful for delivering biologically active molecules to the cytoplasm of cells and promoting release of the biologically active molecules from the endo-lysosomal pathway.