The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
Apr. 27, 2017
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
June L. Round, Salt Lake City, UT (US);
Sarkis K. Mazmanian, Porter Ranch, CA (US);
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C12N 5/0783 (2010.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 39/0008 (2013.01); C12N 5/0637 (2013.01); A61K 35/12 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/6087 (2013.01); C12N 2501/90 (2013.01);
Abstract
Antigen specific regulatory T cells are described and related compositions, methods and systems. Methods to generate an antigen specific anti-inflammatory regulatory T cell is provided, the method comprising contacting either a T cell or an antigen presenting cell with a zwitterionic polysaccharide conjugated to the antigen for a time and under condition to generate an antigen specific regulatory T cell that is capable of inhibiting a pro-inflammatory response against the antigen.