The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 31, 2021

Filed:

Aug. 25, 2017
Applicants:

Exciva (Ug) (Haftungsbeschränkt), Heidelberg, DE;

Sreenivasarao Vepachedu, Vernon Hills, IL (US);

Inventors:

Sreenivasarao Vepachedu, Vernon Hills, IL (US);

Hans J Moebius, Wollerau, CH;

Anton Bespalov, Heidelberg, DE;

Assignee:

Other;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 47/58 (2017.01); A61P 25/28 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61K 31/138 (2006.01); A61K 31/225 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 31/138 (2013.01); A61K 31/225 (2013.01); A61K 45/06 (2013.01); A61K 47/585 (2017.08); A61P 9/00 (2018.01); A61P 25/00 (2018.01); A61P 25/28 (2018.01);
Abstract

Compounds of Formula I: or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of formula I and a compound of Formula II: or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof. Compositions and methods for improving the efficacy of DEX, or providing beneficial pharmacokinetic effects to DEX, comprising co-administering a compound of formula I or SARPO, and a compound of Formula II or DEX to a subject in need thereof, and dosage forms, drug delivery systems, methods of treatment thereof.


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