The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 24, 2021

Filed:

Jul. 03, 2017
Applicant:

Astute Medical, Inc., San Diego, CA (US);

Inventors:

Joseph Anderberg, Encinitas, CA (US);

Jeff Gray, Solana Beach, CA (US);

Paul McPherson, Encinitas, CA (US);

Kevin Nakamura, Cardiff by the Sea, CA (US);

James Patrick Kampf, San Diego, CA (US);

Assignee:

Astute Medical, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 31/00 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); G01N 33/70 (2006.01); G16B 40/00 (2019.01); G16H 50/20 (2018.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); G01N 33/70 (2013.01); G16B 40/00 (2019.02); G16H 50/20 (2018.01); G01N 2333/4703 (2013.01); G01N 2333/4745 (2013.01); G01N 2333/65 (2013.01); G01N 2333/8146 (2013.01); G01N 2800/347 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01); Y02A 90/10 (2018.01);
Abstract

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.


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