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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11098369 B1

PDFFull Text
Date of Patent:
Aug. 24, 2021

Filed:

Aug. 17, 2018

Methods for evaluating tumor cell spheroids using 3d microfluidic cell culture device

Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

David Barbie, Andover, MA (US);

Russell W. Jenkins, Boston, MA (US);

Cloud P. Paweletz, Boston, MA (US);

Elena Ivanova, Brookline, MA (US);

Amir Aref, Malden, MA (US);

Assignee:

Dana-Farber Cancer Institute, Inc., Boston, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Joseph G Dauner

Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); C12M 3/06 (2006.01); C12N 1/04 (2006.01); C12N 9/64 (2006.01); C12Q 1/6869 (2018.01); C12Q 1/6881 (2018.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12M 23/16 (2013.01); C12N 1/04 (2013.01); C12N 9/6491 (2013.01); C12Q 1/6869 (2013.01); C12Q 1/6881 (2013.01); G01N 33/5082 (2013.01); G01N 33/582 (2013.01); C12Y 304/24007 (2013.01);
Abstract

Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.

Find Patent Forward Citations

Barbie, David. (2021). Methods for evaluating tumor cell spheroids using 3d microfluidic cell culture device (U.S. Patent No. 11098369). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11098369

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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