The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
Jun. 27, 2018
The George Washington University, Washington, DC (US);
Washington University IN St. Louis, St. Louis, MO (US);
George Mason University, Fairfax, VA (US);
Saint Louis University, St. Louis, MO (US);
Cynthia Dowd, Washington, DC (US);
Xu Wang, Washington, DC (US);
Robert Carl Brothers, Washington, DC (US);
Audrey Ragan Odom John, St. Louis, MO (US);
Rachel Edwards, St. Louis, MO (US);
Marvin Meyers, St. Louis, MO (US);
Stacy Arnett, St. Louis, MO (US);
Robin Couch, Fairfax, VA (US);
Kenneth Heidel, Washington, DC (US);
The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, Washington, DC (US);
Washington University, St. Louis, MO (US);
George Mason University, Fairfax, VA (US);
St. Louis University, St. Louis, MO (US);
Abstract
The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species andor relatedbacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.