The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
Aug. 23, 2018
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Jiangsu, CN;
Centaurus Biopharma Co., Ltd., Beijing, CN;
Lianyungang Runzhong Pharmaceutical Co., Ltd., Jiangsu, CN;
Liguang Dai, Beijing, CN;
Xiaowei Duan, Beijing, CN;
Yanqing Yang, Beijing, CN;
Xijie Liu, Beijing, CN;
Hongjuan Li, Beijing, CN;
Na Zhao, Beijing, CN;
Yinghui Sun, Beijing, CN;
Fansheng Kong, Beijing, CN;
Jiuqing Zhang, Beijing, CN;
Yizhong Zhu, Jiangsu, CN;
Ling Yang, Jiangsu, CN;
Fei Liu, Jiangsu, CN;
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., Jiangsu, CN;
CENTAURUS BIOPHARMA CO., LTD., Beijing, CN;
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., Jiangsu, CN;
Abstract
The present application relates to a macrocycle containing aminopyrazole and pyrimidine, which is represented by formula (I), a pharmaceutical composition thereof, and a use thereof in inhibiting tropomyosin receptor kinase (Trk) activity and in treating diseases in mammals that are mediated by Trk.