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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11098045 B1

PDFFull Text
Date of Patent:
Aug. 24, 2021

Filed:

Jun. 11, 2020

Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof

Applicant:

Pharmaxis Ltd., Frenchs Forest, AU;

Inventors:

Alison Dorothy Findlay, Frenchs Forest, AU;

Craig Ivan Turner, Frenchs Forest, AU;

Mandar Deodhar, Frenchs Forest, AU;

Jonathan Stuart Foot, Frenchs Forest, AU;

Wolfgang Jarolimek, Frenchs Forest, AU;

Wenbin Zhou, Frenchs Forest, AU;

Alan Duncan Robertson, Warrawee, AU;

Assignee:

Pharmaxis Ltd., Frenchs Forest, AU;

Attorneys:

Gary J. Gershik

Cooper & Dunham LLP

Primary Examiner:

Golam M Shameem

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 45/06 (2006.01); C07D 209/42 (2006.01); A61P 1/16 (2006.01); A61P 13/12 (2006.01); A61P 11/00 (2006.01); A61K 31/4025 (2006.01); A61K 31/4045 (2006.01); A61K 31/41 (2006.01); A61K 31/4245 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/506 (2006.01); C07D 209/14 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 413/10 (2006.01); A61K 31/5025 (2006.01); A61K 31/519 (2006.01); C07D 209/20 (2006.01); C07D 209/36 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/4025 (2013.01); A61K 31/4045 (2013.01); A61K 31/41 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61P 1/16 (2018.01); A61P 11/00 (2018.01); A61P 13/12 (2018.01); C07D 209/14 (2013.01); C07D 209/20 (2013.01); C07D 209/36 (2013.01); C07D 209/42 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 413/10 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

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