The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
Mar. 20, 2018
Applicant:
Arbutus Biopharma Corporation, Burnaby, CA;
Inventors:
Andrew G. Cole, Cranbury, NJ (US);
Bruce D. Dorsey, Ambler, PA (US);
Ramesh Kakarla, Doylestown, PA (US);
Steven Kultgen, Hamilton, NJ (US);
Jorge Quintero, Sayreville, NJ (US);
Assignee:
Arbutus Biopharma Corporation, Burnaby, CA;
Primary Examiner:
Int. Cl.
CPC ...
C07C 271/24 (2006.01); A61K 31/27 (2006.01); A61K 45/06 (2006.01); A61K 31/16 (2006.01); C07C 237/48 (2006.01); A61K 31/167 (2006.01); C07D 213/55 (2006.01); A61K 31/4402 (2006.01); C07D 207/267 (2006.01); C07C 313/06 (2006.01); A61K 31/4015 (2006.01); C07D 207/27 (2006.01); C07D 207/06 (2006.01); A61K 31/40 (2006.01); C07D 213/643 (2006.01); A61K 31/44 (2006.01); C07D 213/73 (2006.01); A61K 31/5377 (2006.01); C07D 211/34 (2006.01); A61K 31/445 (2006.01); C07D 471/04 (2006.01); A61K 31/437 (2006.01); C07D 231/20 (2006.01); A61K 31/415 (2006.01); C07D 213/89 (2006.01); C07D 277/24 (2006.01); A61K 31/426 (2006.01); C07D 263/32 (2006.01); A61K 31/42 (2006.01); C07D 215/14 (2006.01); A61K 31/47 (2006.01); C07D 241/12 (2006.01); A61K 31/4965 (2006.01); C07D 239/26 (2006.01); A61K 31/505 (2006.01); C07D 249/08 (2006.01); A61K 31/4196 (2006.01); C07D 265/30 (2006.01); A61K 31/5375 (2006.01); C07D 205/08 (2006.01); A61K 31/397 (2006.01); C07D 279/12 (2006.01); A61K 31/54 (2006.01); C07C 311/10 (2006.01); A61K 31/18 (2006.01); C07D 487/04 (2006.01); A61K 31/519 (2006.01); C07D 409/12 (2006.01); A61K 31/4436 (2006.01); C07D 235/02 (2006.01); A61K 31/4184 (2006.01);
U.S. Cl.
CPC ...
C07C 271/24 (2013.01); A61K 31/16 (2013.01); A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/27 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/4015 (2013.01); A61K 31/415 (2013.01); A61K 31/4184 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/426 (2013.01); A61K 31/437 (2013.01); A61K 31/44 (2013.01); A61K 31/4402 (2013.01); A61K 31/445 (2013.01); A61K 31/4436 (2013.01); A61K 31/47 (2013.01); A61K 31/4965 (2013.01); A61K 31/505 (2013.01); A61K 31/519 (2013.01); A61K 31/5375 (2013.01); A61K 31/5377 (2013.01); A61K 31/54 (2013.01); A61K 45/06 (2013.01); C07C 237/48 (2013.01); C07C 311/10 (2013.01); C07C 313/06 (2013.01); C07D 205/08 (2013.01); C07D 207/06 (2013.01); C07D 207/267 (2013.01); C07D 207/27 (2013.01); C07D 211/34 (2013.01); C07D 213/55 (2013.01); C07D 213/643 (2013.01); C07D 213/73 (2013.01); C07D 213/89 (2013.01); C07D 215/14 (2013.01); C07D 231/20 (2013.01); C07D 235/02 (2013.01); C07D 239/26 (2013.01); C07D 241/12 (2013.01); C07D 249/08 (2013.01); C07D 263/32 (2013.01); C07D 265/30 (2013.01); C07D 277/24 (2013.01); C07D 279/12 (2013.01); C07D 409/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.